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More Glowing Cells: Chemistry Comes Through Again

Posted on October 09, 2008

I ve spoken before about the acetylene-azide click reaction popularized by Barry Sharpless and his co-workers out at Scripps. This has been taken up by the chemical biology field in a big way, and all sorts of ingenious applications are starting to emerge. The tight, specific ligation reaction that forms the triazole lets you modify biomolecules with minimal disruption (by hanging an azide or acetylene from them, both rather small groups), and tag them later on in a very controlled way.Adrian Salic and co-worker Cindy Yao have just reported an impressive example. They ve been looking...

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amino acids , protein , proteins