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X-Ray Structures: Handle With Care

Posted on September 04, 2008

X-ray crystallography is wonderful stuff I think you ll get chemists to generally agree on that. There s no other technique that can provide such certainty about the structure of a compound and for medicinal chemists, it has the invaluable ability to show you a snapshot of your drug candidate bound to its protein target. Of course, not all proteins can be crystallized, and not all of them can be crystallized with drug ligands in them. But an X-ray structure is usually considered the last word, when you can get one and thanks to automation, computing power, and to brighter X-ray...

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