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Dronedarone Granted Reprieve

Posted on August 08, 2008

It seems Sanofi-Aventis's amiodarone analog drug, dronedarone (marketed as Multaq ), was granted a stay of execution by the FDA:Multaq appeared at one stage to have little future, after an early clinical trial showed excess mortality and the drug was rebuffed by regulators.As we recall:Dronedarone is structurally similar to amiodarone but lacking the iodine moiety a feature of amiodarone that has been linked to many non-cardiac side effects (including pulmonary toxicity, ocular effects, thyroid disease, and hepatic dysfunction). The Dronedarone Atrial Fibrillation Study After Electrical C...

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congestive heart failure , thyroid