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Tiotropium (Spiriva) Treatment in Chronic Obstructive Pulmonary Disease (COPD)

Posted on October 08, 2008

Tiotropium is a once-daily, inhaled anticholinergic drug that provides at least 24-hour improvements in airflow and hyperinflation in patients with COPD. Tiotropium bromide capsules for inhalation are co-marketed by Boehringer-Ingelheim and Pfizer under the trade name Spiriva.The NEJM published a randomized, double-blind trial of 4 years of therapy with either tiotropium or placebo in 5993 adults with COPD. Mean age was 65 years and mean FEV1 was 1.32 liters after bronchodilation (48% of predicted value).A recent meta-analysis published in JAMA that included 14,783 patients with COPD found tha...

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allergy , asthma , chronic obstructive pulmonary disease , copd , heart attack , lung , stroke